Flip-flop on Celsion

It is no secret that I was an outspoken bull on Celsion for the last three years.
While I have quite a lot of sympathy for current shareholders, I personally am 100% out of the stock right now. I had a good exchange with a current bull, and thought it would make the basis for an interesting post.

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Most important, first:
>>did you flip around and go short?

Nope - I never short.
At the absolute most if I am quite certain of a decline I'll buy puts. Don't *like* the idea or process of shorting - too many problems/games that can be played but I guess this is not the time or place for that. [TH - I have PLENTY of posts here over the years to illustrate my issues with shorting]

>>Did you ever consider that PFS in the control group as a whole was 14.4, BUT what if it is less in other subsets? Such as China's 200 patients? What if PFS in the China subset is only 12?

I considered it, and here's my take:

We had very convincing arguments that we'd be golden if PFS came in anywhere under 17 months or so. (Perhaps you'll recall that although I was extremely bullish my own continued mantra was we should expect around a 14:24 PFS. My control arm projection was almost spot on - but with "not even close" we obviously made some kind of dreadful miscalculation of the hazard ratio.)

So given that 14.4 wasn't close, I hold out very diminishing hopes that even a clear subset at 12 would have been stat-sig.
Add to that, that for a 200 patient subset to achieve 12 when the overall was 14.4, the ex-Chinese group would have been even worse than 14.4.

And the DMC at interim did not halt for failure, which if we weren't close at 14.4, with a subset of ~500 out of 600 at the time showing a 15+ PFS ... I propose that such a situation simply couldn't have happened.

And finally:
>>They will not go bankrupt. They have a lot of cash now, 2 ongoing trials, RCW is VERY promising, and probably what they should have focused on in the first place.....

You are right, BK is not going to happen. But massive dilution has happened, and that cash will disappear faster that you might think. ABLATE is only 80?? patients but they were slow to enroll to conserve cash for HEAT results. Gearing up now cost $. And that is ph2, which they were depending on good HEAT results to allow off-label. By itself ABLATE is not registrational. More money needed! And if you'll recall, even the BS BiotechSage admitted HCC ph1 looked decent and it was MLC and distant mets that posed the problem.

I agree that RCW may be the best shot. But they took ... so ... long ... to enroll even the ph1, I don't see the larger ph2 finishing with results anytime before 2016.

I put a HUGE amount of time, attention, and DD into the bull case. But I am always cogent about what might happen and once the "unthinkable" happened then I have to put credence in the bear case until proved wrong (again). The reward is definitely there, at this price, but the risk is, in my opinion, much worse.

GLTY
Trond

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So there you go. I followed my principles and took my basis out in the $7s and $8s, but for three years, and the time and effort I put into this, I am not sure I "got my money's worth" here. Another lesson in the minefield called biotech.

Best,
Trond Hildahl

** This is presented for educational and informational purposes only, and should not be construed as personalized legal, tax, investment, or financial advice. My own resources, risk tolerance, and personal situation have been taken into consideration for any trades mentioned and should not be used as a basis for someone else's trades. Stocks may lose value and this is not recommendation to buy or sell this particular issue.